@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Z_NR1I1_VDRB: (2019-06-04 )
MESAVSTSTQVPDEFDRNVPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGSCTITKDNRRHCQACRLKRCLDIGMMKEFILTDEEVQRKKELIQRRKDEEAHREAQKPRLSDEQRNIIDTLVDAHHKTYDDSYSDFSRFRPPVREGPVTRSASRAASLHSLSDASSDSFSHSPESGDRKMNLSNLLMMYQEQGLSSSPDSKEEDGSSLSMLPHLADLVSYSIQKVIGFAKMIPGFRELTAEDQIALLKSSAIEVIMLRSNQSFSLEDMSWSCGGPEFKYCVNDVTKAGHTLELLEPLVKFQVGLKKLNLHEEEHVLLMAICLLSPDRPGVQDHVRVEALQDKVSEVLQAYIRAHHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGGQVT
Atome Classification :
(108 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360......--.--370.........380.......390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MESAVSTSTQV
P
D
E
FDRNV
P
R
I
C
GVCGDKAT
G
F
H
FNAM
T
C
E
G
C
K
G
F
F
R
R
S
M
K
RKA
S
F
TCPFNG
S
C
T
ITKDN
R
R
H
C
Q
A
C
R
L
K
R
C
L
D
I
G
M
M
K
E
F
ILT
D
E
E
V
Q
R
K
K
E
L
I
Q
RRK
D
E
E
A
H
R
E
AQKPRL
S
D
E
Q
R
N
I
I
D
T
L
V
D
A
HHKTYDDSY
S
D
F
S
RFRPPVREGPVTRSA
S
R
A
A
SLHSLSDASSDSFSHSPESGDRKM
N
L
S
N
L
L
M
M
Y
Q
E
QGLSSSPDSKEEDGS
S
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
MI
P
G
F
R
E
LTA
E
D
Q
I
A
L
L
KSS
A
I
E
V
I
M
L
RSNQSFSLEDMSWSCGGP
E
F
K
Y
C
V
N
D
V
T
KAG
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
KLNLHEE
E
H
V
L
L
M
A
I
C
LLSPDRPG
V
Q
D
H
V
R
V
E
A
L
Q
D
K
V
S
E
V
L
Q
A
Y
I
R
AHH--P--G--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
RSLSFQPEHSM
Q
L
T
P
L
V
L
E
V
FGGQVT
14
PsiBlast_PDB
83.46
88%
-136
- C6 -
-
5LGA
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
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Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
L
S
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A
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E
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Q
I
A
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S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
21
Blastp_CBE
83.10
88%
-129
- C6 -
-
5OWD
1
VDRA_DANRE
A:
[5-302]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
27
Blastp_CBE
82.70
88%
-130
- C6 -
-
3O1E
1
VDRA_DANRE
A:
[5-302]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
106
HHSearch
81.98
88%
-128
* C6 *
-
4Q0A
2
VDRA_DANRE
C:
[7-301]
----------------------------------------------------------------------------------------------------------------------------
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
--------------------------------------------------------------
R
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
107
HHSearch
81.50
88%
-130
- C6 -
-
4IA2
1
VDRA_DANRE
A:
[7-299]
------------------------------------------------------------------------------------------------------------------------------
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
--------------------------------------------------------------
R
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
23
Blastp_CBE
78.86
88%
-36
- C6 -
-
5OW7
1
VDRA_DANRE
A:
[5-302]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
22
Blastp_CBE
78.75
88%
-37
- C6 -
-
5OW9
1
VDRA_DANRE
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
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Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
33
Blastp_CBE
78.16
88%
-37
- C6 -
-
4RUO
1
VDRA_DANRE
X:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
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E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
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L
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D
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Y
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V
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F
A
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C
G
G
P
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K
Y
C
I
N
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V
T
K
A
G
H
T
L
E
H
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
52
Blastp_CBE
78.10
62%
-112
- C6 -
-
2HAR
1
VDR_HUMAN
A:
[6-259]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P----
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
19
PsiBlast_PDB
78.10
88%
-37
- C6 -
-
6FOD
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
18
PsiBlast_PDB
78.00
88%
-33
- C6 -
-
6FOB
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
1
PsiBlast_PDB
77.93
88%
-33
- C6 -
-
4FHH
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
28
Blastp_CBE
77.71
88%
-29
- C6 -
-
3O1D
1
VDRA_DANRE
A:
[5-302]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
26
Blastp_CBE
77.70
88%
-32
- C6 -
-
4Q0A
2
VDRA_DANRE
C:
[5-302]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
24
Blastp_CBE
77.70
88%
-27
- C6 -
-
5NMA
1
VDRA_DANRE
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
10
PsiBlast_PDB
77.70
88%
-34
- C6 -
-
4IA2
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
5
PsiBlast_PDB
77.69
88%
-39
- C6 -
-
4G1Z
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
32
Blastp_CBE
77.63
88%
-35
- C6 -
-
4RUP
1
VDRA_DANRE
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
H
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
29
Blastp_CBE
77.62
88%
-33
- C6 -
-
3DR1
1
VDRA_DANRE
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
6
PsiBlast_PDB
77.59
88%
-42
- C6 -
-
4G20
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
4
PsiBlast_PDB
77.52
88%
-38
- C6 -
-
4G1Y
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
17
PsiBlast_PDB
77.51
88%
-33
- C6 -
-
6FO9
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
13
PsiBlast_PDB
77.51
88%
-31
- C6 -
-
5E7V
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
15
PsiBlast_PDB
77.48
88%
-34
- C6 -
-
6FO7
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
11
PsiBlast_PDB
77.38
88%
-29
- C6 -
-
4IA3
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
9
PsiBlast_PDB
77.36
88%
-32
- C6 -
-
4IA1
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
31
Blastp_CBE
77.35
88%
-34
- C6 -
-
2HC4
1
VDRA_DANRE
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
34
Blastp_CBE
77.31
88%
-29
- C6 -
-
4RUJ
1
VDRA_DANRE
A:
[5-302]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
H
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
25
Blastp_CBE
77.24
88%
-34
- C6 -
-
5NKY
1
VDRA_DANRE
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
30
Blastp_CBE
77.14
88%
-35
- C6 -
-
2HCD
1
VDRA_DANRE
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
98
Blastp_CBE
77.02
63%
-81
- C6 -
-
5GT4
1
VDR_HUMAN
A:
[1-255]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
12
PsiBlast_PDB
76.98
88%
-32
- C6 -
-
4IA7
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
38
Blastp_CBE
76.94
62%
-89
- C6 -
-
3X31
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
-----------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
88
Blastp_CBE
76.92
64%
-82
- C6 -
-
3B0T
1
VDR_HUMAN
A:
[1-254]
---------------------------------------------------------------------------------------------------------------------
A
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
81
Blastp_CBE
76.87
62%
-78
- C6 -
-
3TKC
1
?
A:
[2-255]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
82
Blastp_CBE
76.86
62%
-77
- C6 -
-
3OGT
1
VDR_HUMAN
A:
[2-255]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
97
Blastp_CBE
76.82
63%
-78
- C6 -
-
5YSY
1
VDR_HUMAN
A:
[1-255]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
51
Blastp_CBE
76.79
62%
-83
- C6 -
-
2HAS
1
VDR_HUMAN
A:
[6-259]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP---
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
39
Blastp_CBE
76.74
62%
-85
- C6 -
-
3WWR
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
-----------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
47
Blastp_CBE
76.71
62%
-78
- C6 -
-
3A40
1
VDR_HUMAN
X:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
91
Blastp_CBE
76.70
64%
-81
- C6 -
-
3W0C
1
VDR_HUMAN
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
3
PsiBlast_PDB
76.67
88%
-35
- C6 -
-
4G1D
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
2
PsiBlast_PDB
76.66
88%
-40
- C6 -
-
4FHI
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
96
Blastp_CBE
76.64
63%
-79
- C6 -
-
5YT2
1
VDR_HUMAN
A:
[1-255]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
48
Blastp_CBE
76.62
62%
-81
- C6 -
-
3A3Z
1
VDR_HUMAN
X:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
37
Blastp_CBE
76.57
62%
-82
- C6 -
-
3X36
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
-----------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
8
PsiBlast_PDB
76.54
88%
-33
- C6 -
-
4G2H
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
84
Blastp_CBE
76.53
62%
-78
- C6 -
-
1IE9
1
VDR_HUMAN
A:
[1-255]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
89
Blastp_CBE
76.50
64%
-81
- C6 -
-
3WGP
1
VDR_HUMAN
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
7
PsiBlast_PDB
76.50
88%
-33
- C6 -
-
4G21
1
VDRA_DANRE
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
95
Blastp_CBE
76.49
64%
-84
- C6 -
-
3AZ1
1
VDR_HUMAN
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
43
Blastp_CBE
76.48
62%
-85
- C6 -
-
3AX8
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
------------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
90
Blastp_CBE
76.45
64%
-82
- C6 -
-
3W0Y
1
VDR_HUMAN
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
53
Blastp_CBE
76.44
62%
-82
- C6 -
-
2HAM
1
VDR_HUMAN
A:
[6-259]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP---
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
50
Blastp_CBE
76.43
62%
-81
- C6 -
-
2HB7
1
VDR_HUMAN
A:
[6-259]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
103
Blastp_CBE
76.40
62%
-88
- C6 -
-
5V39
1
VDR_HUMAN
A:
[4-254]
------------------------------------------------------------------------------------------------------------------------
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
------
P
P
V
R
V
N
D
G
G
G
S
V
--------------------------
T
L
E
L
L
Q
------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
79
Blastp_CBE
76.34
63%
-87
- C6 -
-
5GIE
1
VDR_RAT
A:
[1-256]
-------------------------------------------------------------------------------------------------------------------
K
D
S
L
R
P
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
D
G
S
--
S
V
T
L
D
L
S
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
---
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
56
Blastp_CBE
76.34
62%
-83
- C6 -
-
1S0Z
1
VDR_HUMAN
A:
[7-259]
----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
41
Blastp_CBE
76.32
62%
-80
- C6 -
-
3CS6
1
VDR_HUMAN
A:
[6-259]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
20
PsiBlast_PDB
76.27
88%
-29
- C6 -
-
2HBH
1
VDRA_DANRE
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
---------------------------------------------------------------R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
--
G
--
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
80
Blastp_CBE
76.20
62%
-84
- C6 -
-
4G2I
1
VDR_HUMAN
A:
[3-255]
----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
36
Blastp_CBE
76.15
62%
-85
- C6 -
-
4ITE
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
------------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
92
Blastp_CBE
76.11
64%
-84
- C6 -
-
3W0A
1
VDR_HUMAN
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
94
Blastp_CBE
76.10
64%
-81
- C6 -
-
3AZ2
1
VDR_HUMAN
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
46
Blastp_CBE
76.10
62%
-79
- C6 -
-
3A78
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
54
Blastp_CBE
76.09
62%
-83
- C6 -
-
1TXI
1
VDR_HUMAN
A:
[7-259]
----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
49
Blastp_CBE
76.08
62%
-81
- C6 -
-
2HB8
1
VDR_HUMAN
A:
[6-259]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
93
Blastp_CBE
76.06
64%
-83
- C6 -
-
3AZ3
1
VDR_HUMAN
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
55
Blastp_CBE
76.02
62%
-84
- C6 -
-
1S19
1
VDR_HUMAN
A:
[7-259]
----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
86
Blastp_CBE
76.01
62%
-85
- C6 -
-
1DB1
1
VDR_HUMAN
A:
[3-255]
----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
77
Blastp_CBE
75.90
62%
-82
- C6 -
-
3P8X
1
VDR_HUMAN
A:
[22-276]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
35
Blastp_CBE
75.77
62%
-86
- C6 -
-
4ITF
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
------------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
85
Blastp_CBE
75.69
62%
-80
- C6 -
-
1IE8
1
VDR_HUMAN
A:
[3-255]
----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
-------
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
83
Blastp_CBE
75.65
62%
-83
- C6 -
-
3KPZ
1
VDR_HUMAN
A:
[3-255]
----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
99
Blastp_CBE
75.63
61%
-79
- C6 -
-
3A2J
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
------------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
F
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
42
Blastp_CBE
75.62
62%
-80
- C6 -
-
3CS4
1
VDR_HUMAN
A:
[6-259]
---------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
44
Blastp_CBE
75.57
62%
-84
- C6 -
-
3AUR
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
------------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
40
Blastp_CBE
75.53
62%
-77
- C6 -
-
3VHW
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
-----------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
45
Blastp_CBE
75.10
62%
-81
- C6 -
-
3AUQ
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
------------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
101
Blastp_CBE
75.07
63%
-78
- C6 -
-
3M7R
1
VDR_HUMAN
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
G
----------
G
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
Q
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
87
Blastp_CBE
74.96
62%
-84
- C6 -
-
3A2I
1
VDR_HUMAN
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
----------------
V
N
D
G
------------
S
V
T
L
E
L
S
Q
L
------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
64
Blastp_CBE
74.58
62%
-90
- C6 -
-
5XZH
1
VDR_RAT
A:
[16-267]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
102
Blastp_CBE
74.34
64%
-91
- C6 -
-
5GID
1
VDR_RAT
A:
[1-249]
--------------------------------------------------------------------------------------------------------------------------
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
76
Blastp_CBE
74.31
62%
-90
- C6 -
-
2ZL9
1
VDR_RAT
A:
[18-267]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
100
Blastp_CBE
74.05
64%
-92
- C6 -
-
5GIC
1
VDR_RAT
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
73
Blastp_CBE
74.05
62%
-88
- C6 -
-
3VJT
1
VDR_RAT
A:
[18-268]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
75
Blastp_CBE
74.03
62%
-83
- C6 -
-
2ZLA
1
VDR_RAT
A:
[18-268]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
66
Blastp_CBE
73.92
62%
-93
- C6 -
-
5XUQ
1
VDR_RAT
A:
[18-267]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------------------
S
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
-------
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
62
Blastp_CBE
73.80
62%
-93
- C6 -
-
5ZWH
1
VDR_RAT
A:
[18-268]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
74
Blastp_CBE
73.75
62%
-80
- C6 -
-
3VJS
1
VDR_RAT
A:
[18-269]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
67
Blastp_CBE
73.73
62%
-79
- C6 -
-
5XPM
1
VDR_RAT
A:
[18-268]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------------------
S
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
69
Blastp_CBE
73.59
62%
-81
- C6 -
-
4YNK
1
VDR_RAT
A:
[18-269]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
59
Blastp_CBE
73.49
62%
-88
- C6 -
-
1RK3
1
VDR_RAT
A:
[8-258]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
60
Blastp_CBE
73.43
62%
-81
- C6 -
-
1RJK
1
VDR_RAT
A:
[8-258]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
70
Blastp_CBE
73.41
62%
-92
- C6 -
-
3VRW
1
VDR_RAT
A:
[18-267]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
65
Blastp_CBE
73.41
62%
-86
- C6 -
-
5XZF
2
VDR_RAT
A:
[18-267]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
61
Blastp_CBE
73.41
62%
-83
- C6 -
-
3A2H
1
VDR_RAT
A:
[12-263]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
57
Blastp_CBE
73.28
62%
-77
- C6 -
-
2O4R
1
VDR_RAT
A:
[8-259]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
63
Blastp_CBE
73.26
62%
-81
- C6 -
-
5ZWF
1
VDR_RAT
A:
[18-268]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
68
Blastp_CBE
73.23
62%
-85
- C6 -
-
5B41
1
VDR_RAT
A:
[18-268]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
71
Blastp_CBE
73.13
62%
-92
- C6 -
-
3VRV
1
VDR_RAT
A:
[18-267]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
72
Blastp_CBE
73.08
62%
-90
- C6 -
-
3VRU
1
VDR_RAT
A:
[18-268]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
--------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
58
Blastp_CBE
73.03
62%
-81
- C6 -
-
2O4J
1
VDR_RAT
A:
[8-259]
-------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-------------------------------------------------
M
------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
78
Blastp_CBE
72.18
63%
-102
- C6 -
-
5GIE
1
VDR_RAT
D:
[8-256]
--------------------------------------------------------------------------------------------------------------------------
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
----------------------------------------------------------------
P
-
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
----
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
PP
P
--
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
110
HHSearch
69.32
81%
-108
- C6 -
-
3B0T
1
VDR_HUMAN
A:
[55-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
--
P
--
P
PG
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
111
HHSearch
69.28
81%
-107
- C6 -
-
5YSY
1
VDR_HUMAN
A:
[56-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
--
P
--
P
PG
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
112
HHSearch
68.23
82%
-101
- C6 -
-
5GID
1
VDR_RAT
A:
[51-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
--
P
PP
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
108
HHSearch
67.53
81%
-87
- C6 -
-
2O4J
1
VDR_RAT
A:
[59-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
--
P
PP
G
--
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--