Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREK--QSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEA----NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQR-----PMLREVLEHPWITANSSKPSNCQNKESASKQS 6C0T Chain:A ((33-295)) ---------------------------------------------------------------------------------------------------------------------------------LSDFNIIDTLGVGGFGRVELVQLKSEESK-TFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE--FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF--------------------

General information: TITO was launched using: RESULT: Template: 6C0T.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1247 6269 5.03 24.97 target 2D structure prediction score : 0.73 Monomeric hydrophicity matching model chain A : 0.73 3D Compatibility (PKB) : 5.03 2D Compatibility (Sec. Struct. Predict.) : 0.73 1D Compatibility (Hydrophobicity) : 0.73 QMean score : 0.280

(partial model without unconserved sides chains): PDB file : Tito_6C0T.pdb: (Unconserved sides chains are recalculated) : Sequence: align-6c0t-query.scw PDB file : Tito_Scwrl_6C0T.pdb: