Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKI--PSPVKLAFIDNLHHLCK-HLDFRE-DETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVK-LQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRT-LGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNE-------TEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILAS----FASSDDPYQGPRDIISPELMADYLQPK-------------------LLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYF-LPDH-------P----------ELKKIKAVLQEYRKETSESTDLQTTL--------QLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPIISQ----LVTVLLKGC--QD-ANSQARLLCGECLGELGAIDPGRLDFSTTETQG-KDFTFVTGVEDSSFAYG-LLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGHQLW-RRFPEHVREILEPHLNTRYKSSQKST---DWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQI--LEHESLGLLRDATACYDRAIQLEPD--QIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQED--SLNWV-ARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV----------GECWLQSARVARKAGHHQTAYNALLNAGESRL----------------AELYVERAKWLWSKGDVHQALIVLQKGVELCFPENETP--PE---GKNMLIHGRAMLLVGRFMEETANFESNAIMKKYK----DVTACLPEWEDGHFYLAKYYDKLMPMVTDN----K-----------------------------------------M-EKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSS--------YPMRVNRCKEILNKAIHMK--KSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEIL-ASLQKPKKISLKGSDGKFYIMMCKP-KDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKS-AALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 6JXC Chain:A ((928-2787)) ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDILDWIISRFEDNSFTGVAPTVNLSMLLLSLLQNHDLSHGSIRGGKQRVFATFIKCLQKLDSSNIINIMNSISSYMAQVSYK---NQSIIFYEIKSLFGP--PQQSIEKSAFYSLAMSMLSLVS-YPSLVFSLEDMMTYSG--FNHTRAFIQQALNKITVAFRYQNLTELFEYCKFDLIMYWF-------------------------------------------------HEFLGRYFVEISAIYFSQGF--NQKWILDMLHAITGNGDAYLVDNSYYLCIPLAFISGGVN--ELIFDILPQISGKTTVKYHKKYRLLMLKWI--IRFTDLGSLTELRSTVEKLFPTSYLSPYLFENSS--------VSMRYQYPLHIPLALGATLVQTQFAHEKNNTHEFKLLFLSVITDLEK-TSTYIGKLRCARELKYLFVLYENVLVK-------------------------------------SSTLNFIIIRLSKFLID-TQIHDEVITIFSSLLNLADKNTFEIEPSLPNLFCKIFIYLRENKQLSPSFQQAIKLLEHRDLIKIKTWKYCLD-AIFGNIVQDDIYENTELLD-ASDCGVD-D----VVLVSLLFSYARRPV--------ASKIGCSLSKAAAINILKHHVPKEYLSKNFKLWFAALSRRILQQE-----------HLKNFEMVFRHPEQPHMIYQRISTF-NKEAE-LYDSTEVFFISECILTYLVGYSIGNSESE-----FCFRDNIMNENKDKVAPLDKDVLNAIYPLANNFGMESFICDTYL-SVNEPYNCWLSKFARSLIHQISF--NIPPIVCLYPLCKGSTAFCELVLTDLFFLSTTYDP----KSCLNWSNRIFTQIAMLL------HVKDSEIKLKMLFNVIKMIRMGSRCKER-----------------------------NCLRIYS-SLDLQEICQISLKIKEFKFGYLLFEEMNMPNIR--EMNINTLQKIYECINDGDFLAGLPVP----HSIEGVLNSINR-IDSDTWKRFLFNNADFDANYTTSLEEEKESLIKATEDSGFYGLTSL-LESRLS-G-------SSDVYKWNLELGDWKLLTPKV-----VDSKAKGLYYAIKNLPQDV-GFAEKSLEKSLLTIFDSR-----Q--HFISQTEWMDTLNAIIEFIKIAAIPQDVT--SFPQTLMSIMKADKERL--NTIDFYDHKTTLKSRHTLMNVLSRNSLDENVKCSKYLRLGSIIQLANYVQLAIANGAPQDALRNATLMSKTVKNIAKLYDDPSVVSQIEKLASFTSANALWESREYKAPVMIMRDLLAQNEKNISESILYDDFKLLINVPMDQIKARLVKWSSESRLEPAAAIYEKIIVNWDINVEDHESCSDVFYTLGSFLDEQAQKLRSNGEIEDREHRSYTGKSTLKALELIYKAKRHYNRVLLQYNRDSEVLKALLLQKEKFLWHALHFYLNTLVFSNRYDNDIIDKFCGLWFENDD-------------------NSKINQLLYKEIGTIPSWKFLPWVNQIASKISMEENEFQKPLQLTMKRLLYKLPYDSLYSVMSILLYEKQSNKDTNISQKIQAVKKILLELQGYDRGAFAKKYLLPVQEFCEMSVELANLKFVQNTKTLRLANL-KIGQYWLK------------QLNMEKLPLPTSNFTVKSSADG-RKARPYIVSVNETVGITTTGLSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDKIT--FDQARKGMKAVQTKSNEERLKAYLK-ITNEIKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYSWVMSPVKKYEHLFE----NENQESYRALKGVEEKLMG----------NGLSVESSVQDLIQQATDPSNLSVIYMGWSPFY

General information: TITO was launched using: RESULT: Template: 6JXC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 6970 -29390 -4.22 -18.19 target 2D structure prediction score : 0.55 Monomeric hydrophicity matching model chain A : 0.61 3D Compatibility (PKB) : -4.22 2D Compatibility (Sec. Struct. Predict.) : 0.55 1D Compatibility (Hydrophobicity) : 0.61 QMean score : 0.167

(partial model without unconserved sides chains): PDB file : Tito_6JXC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-6jxc-query.scw PDB file : Tito_Scwrl_6JXC.pdb: